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Primary immunological abnormalities in atopic humans

The primary immunological abnormalities in atopic humans are:  1) Elevated IgE,  2) Higher IgE responses to food allergens,  3) Low numbers of "rosetting" lymphocytes  4) Low numbers of CD8-positive T-cells  5) Increased CD4/CD8 ratio   6) Depressed ConA and histamine-induced suppression 7) Elevated phosphodiesterase and linoleic acid levels in cord blood leucocytes.

References

Bjoerksten, B.: Primary immunological abnormalities in atopic infants. Symposium Paediatric Allergy, 14th Congress of EAACI, Berlin, September 22, 1989.