Λεξικό .. Platelet-activating factor Acetylhydrolase

Platelet-activating factor Acetylhydrolase

Platelet-activating factor (PAF), a phospholipid with a wide range of proinflammatory actions, is immediately degraded and inactivated in vivo by PAF acetylhydrolase (PAF-AH). Acetylhydrolase can catalyse the reconversion of PAF to the inactive lyso-PAF. It has been found reduced PAF acetylhydrolase activity in sera from asthmatic children and hypothesized that this may explain the severity of their asthma.

Plasma platelet-activating factor acetylhydrolase becomes progressively activated as atherosclerosis progresses, but lines of evidence indicate that the enzyme possesses potent antiatherogenic and antiinflammatory properties. This raises the question of whether increased activity is a cause or a result of atherosclerosis and, consequently, whether inhibiting the enzyme's activities may decelerate or accelerate the progress of the disease  
 

Miwa M. Et al: Characterization of serum platelet-activating factor (PAF) acetylhydrolase: correlation between deficiency of serum PAF acetylhydrolase and respiratory symptoms in asthmatic children. J. Clin. Invest. 1988;82:1983-91.

Chen CH. Platelet-activating factor acetylhydrolase: is it good or bad for you? Curr Opin Lipidol. 2004 Jun;15(3):337-41.