Λεξικό .. IL-4 υποδοχέας IL-4 receptor

IL-4 υποδοχέας IL-4 receptor Allergen‐specific immunotherapy (AIT) is the only causal treatment for allergy. However, success rates vary depending on the type of allergy and disease background of the patient. Hence, strategies targeting an increased therapeutic efficacy are urgently needed. Here, the effects of blockade of IL‐4 and IL‐13 signaling on different phases of AIT were addressed.
IL‐4 and IL‐13 blockade during experimental AIT demonstrates beneficial effects on immunological key parameters such as immunoglobulin and cytokine secretion immediately after AIT. Although two weeks later these effects were dropped to those of AIT alone, the number of potentially disease‐triggering Th2‐biased Tregs was further significantly decreased by IL‐4M treatment. Hence, IL‐4/IL13‐targeting therapies prime the immune memory in therapy success‐favoring manner.

Russkamp D, Aguilar-Pimentel A, Alessandrini F, Gailus-Durner V, Fuchs H, Ohnmacht C, Chaker A, de Angelis MH, Ollert M, Schmidt-Weber CB, Blank S. IL-4 receptor α blockade prevents sensitization and alters acute and long-lasting effects of allergen-specific immunotherapy of murine allergic asthma. Allergy. 2019 Mar 4. doi: 10.1111/all.13759. [Epub ahead of print]