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Drug additives

Drug additives may induce pseudoallergic reactions. Kolly et al investigated 1467 frequently administered formulations and they found benzoates in 15% of the formulations, sorbates in 5,5%, sulfites in 3,8% and belzalkonium in 30%. The occurence of the seven artificial colours studied was as follows: indigotin 7,8, erythrosine 7,4, sunset yellow 6,6, tartrazine 4,9, quinoline yellow 2,8%, ponceau (new coccine) 2,6, and amaranth 1,7%. A significant risk of exposure to preservatives and dyes likely to induce asthma, urticaria, or other pseudoallergic reactions exists for all individuals taking commercial drug products. (See additives).

References

Kolly M. et al: Additives contained in drug formulations most frequently prescribed in Switzerland. Ann. of Allergy 62;21-25, 1989.