Λεξικό .. Chlorine gas (Cl2),

Chlorine gas (Cl2),

Exposure to chlorine gas (Cl2) causes occupational asthma that it is hypothesized occurs through the induction of airway inflammation and airway hyperresponsiveness by oxidative damage. Chlorine exposure causes functional and pathological changes in the airways associated with oxidative stress. iNOS is involved in the induction of changes in responsiveness to methacholine[1].

Recent studies have strengthened the evidence of asthma and other adverse respiratory effects in cleaning workers. Similar effects are seen in other settings in which cleaning products are used such as healthcare professionals and homemakers. Both new-onset asthma and work-exacerbated asthma due to cleaning exposures may play a role. Exposure to cleaning sprays, chlorine bleach and other disinfectants may be particularly relevant. The predominant effect mechanisms remain largely unclear and may include both specific sensitization and irritant-related features.

References

1. James G Martin, Holly R Campbell, Hiroaki Iijima, Denyse Gautrin, Jean-Luc Malo, David H Eidelman, Qutayba A Hamid, and Karim Maghni. Chlorine-induced injury to the airways in the mouse Am. J. Respir. Crit. Care Med. 2003, doi:10.1164/rccm.200201-021OC.

2. Zock JP, Vizcaya D, Le Moual N. Update on asthma and cleaners. Curr Opin Allergy Clin Immunol. 2010 Jan 20.