Λεξικό .. CD (Cluster of Differentiation)

The capacity to evaluate lymphocytes subpopulations has been facilitated by the availability of numerous monoclonal reagents that bind specific cell surface antigens. These reagents are now classified with CD (Cluster of differentiation) designation which is assigned by international workshops.

These reagents have dramatically enhanced the capacity to characterize lymphocyte development (ontogeny). The functional role of surface antigens recognized by each CD reagent is also being evaluated and has resulted in the use of certain monoclonal antibodies therapeutically (OKT 3). In a broad sense the monoclonal reagents can be categorized as those that identify developmental antigens, subpopulation (functional) markers or activation antigens.

References

Fleisher, T.A.: Laboratory measurements: Immunoglobulins, Mediators, cell surface Markers, Cell Proliferation and Phagocytosis. Ann. of Allergy, 1991:67:186-189.