Λεξικό .. Can f I.

Can f I. Dogs are a relevant source of allergens, but diagnosing dog-related allergies may present difficulties, as in diagnostic tests with commercial dog allergens, some patients show only slight positive or negative results, even though they suffer from dog-related symptoms. Occasionally, allergy tests with extracts of dog hair belonging to patients' dogs or from dogs of the same breed were found to yield more reliable results, possibly due to breed-specific allergen components An important dog-hair and dander-specific allergen Ag 13 is suggested to be called Can f I. It has been purified by means of immunoaffinity chromatography utilizing rabbit antibody specific for Can f I. This allergen will be a marker allergen for environmental dog hair and dander exposure. See Ag .13 [1]. Notably, the self-prepared extracts of hair of common breeds showed distinct protein bands with a molecular mass lower than 14 kD, which the commercial extracts did not. With regard to Can f 1 content, a marked variability occurred. Factors related to individual dogs seem to influence the allergenicity more than breed or gender [2]. Heutelbeck AR et al (2008 first described allergens with low molecular mass that are absent in extracts of commercial test kits. Consequently, skin tests with self-prepared dog allergen extracts need to be performed in case of inconsistent test results with commercial extracts.

References

1. Schou, C., et al: Purification, and characterization of the major dog allergen, Can f I. Clin. Exper. Allergy (1991) 21, No. 3, p. 321-328.

2. Heutelbeck AR, Schulz T, Bergmann KC, Hallier E.Environmental exposure to allergens of different dog breeds and relevance in allergological diagnostics. J Toxicol Environ Health A. 2008;71(11-12):751-8