Λεξικό .. Beta Adrenergic Theory of Bronchial Asthma

This theory proposes that: 1) The fundamental abnormality of bronchial asthma is hyperreactivity of the bronchial tree to a broad spectrum of immunologic, psychic, infectious, chemical, and physical stimuli which act either directly or through cholinergic reflexes. 2) This hyperreactivity results from diminished responsiveness of the Beta adrenergic receptors of the tracheobronchial tree, including those of the bronchial smooth muscles which normally exert a homeostatic bronchodilating effect against these bronchoconstrictive stimuli. 3) Imprairment of the beta adrenergic receptors in the skin, nose, and lymphoid tissue accounts for the occurrence of the other atopic conditions: atopic dermatitis vasomotor rhinitis, and enhanced IgE production.

References

Nelson, H.S.: The Beta Adrenergic Theory of Bronchial Asthma. Ped. Clin. of N. Am. 22, 1:53-61, 1975.