Λεξικό .. Apoptosis

Programmed cell death. A process associated with endogenous endonuclease activation which leads to macrophage recognition and phagocytosis of the intact senexent cell. Apoptosis is a necessary process to maintain cell numbersin multicellular organisms. In some chronic inflammatory diseases, reduced cell death of different types of granulocytes is one important mechanism for cell accumulation. Patients with ASA-sensitive rhinosinusitis/asthma ("aspirin triad") suffer from particularly severe form of hyperplastic rhinosinusitis with recurrent polyposis.It has been demonstrated that decreased apoptosis of inflammatory cells in nasal polyps from aspirin-sensitive patients may be related to the increased severity, and persistence of nasal inflammation[1, 2].

References

1.Kowalski, M.L et al: Apoptosis and inflammation in nasal polyps from aspirin-sensitive and aspirin-tolerant patients. The Annual Meeting of the European Academy of Allergology and Clinical Immunology, Brussels, Belgium July 3-7, 1999. Allergy Sppl 52:54:11-12, 1999

1.Daigle I., Simon H.-U: A role for caspasesin eosinophil  and neutrophil apoptosis. The Annual Meeting of the European Academy of Allergology and Clinical Immunology, Brussels, Belgium July 3-7, 1999. Allergy Sppl 52:54: 13, 1999