Λεξικό .. Anti-idiotypic antibodies

The set of determinants (singularly called idiotypes) bestowing antigenicity to the combining site (paratope) of each antibody are termed idiotypical and are expressed on the hypervariable regions of immunoglobulins. Their complementary antibodies are the anti-idiotypic antibodies (anti-Id). Idiotypes are therefore antigenic determinants present on B-cell antigen receptors (membrane Ig), but also on T-cells (particularly on T-suppressors) idiotypes are present not only on the membrane structures, but also on the secretion products (Serum Ig, T-cell specific suppressor factors, etc.). Anti-idiotypic monoclonal antibodies (mAb) have been evaluated for actively induced immunotherapy with encouraging results [1]. Anti-idiotypic antibodies, which imitate a tumor-associated antigen by their variable region, offer an elegant method for the induction of a specific immune response, when used as a surrogate antigen for immunization. [2]

References.

1. Fuentes D, Avellanet J, Garcia A, Iglesias N, Gabri MR, Alonso DF, Vazquez AM, Perez R, Montero E. Combined therapeutic effect of a monoclonal anti-idiotype tumor vaccine against NeuGc-containing gangliosides with chemotherapy in a breast carcinoma model. Breast Cancer Res Treat. 2009 Apr 18.

2. Wagner U, Köhler S, Prietl G, Giffels P, Schmidt-Nicolai S, Schlebusch H, Grünn U, Bender H, Biersack HJ, De Potter C, Krebs D, Wallwiener D. Monoclonal anti-idiotype antibodies in immunotherapy of ovarian carcinoma (MAb ACA125) and breast carcinoma (MAb ACA14C5).Zentralbl Gynakol. 1999;121(4):190-5.