Λεξικό .. Anterior Chamber Associated Immune Deviation

Anterior Chamber Associated Immune Deviation

Anterior chamber associated immune deviation (ACAID) is an antigen-specific form of peripheral immune tolerance that is induced to exogenous antigens placed in the ocular anterior chamber, which leads to a suppression in delayed-type hypersensitivity (DTH).

Considerable work has been done on ACAID induction to major histocompatibility (MHC) alloantigens. However, its role on cytotoxic T lymphocyte (CTL) activity is currently unknown. ACAID mediates an inhibition of CTL function against MHC alloantigens. Furthermore, it has been  found that ACAID induction leads to the expansion and proliferation of CD4(+) and CD8(+) T cells while ACAID expression is associated with a diminishment in T cell percentages due to proliferation impairment.

Lastly, Treg also expand during ACAID induction. However, Treg do not directly inhibit CTL activity [1].

By its type of defence against intra-ocular aggressors, assures some protection of the eye and explains the development of some intra-ocular tumours and tolerance to corneal grafts.

References

Saban DR, Cornelius J, Masli S, Schwartzkopff J, Doyle M, Chauhan SK, Peck AB, Grant MB. The role of ACAID and CD4+CD25+FOXP3+ regulatory T cells on CTL function against MHC alloantigens. Mol Vis. 2008;1