Λεξικό .. Allergic reactions

Allergic reactions

Allergic reactions are the result of complex immunologic mechanisms involving cellular and humoral elements. The primary cells of the immune response are lymphocytes, macrophages, esinophils, mast cells and basophils. Humoral immunity involves five classes of immunoglobulin: IgM, IgA, IgD, IgG, and IgE. Preformed (e.g. histamine) and newly formed chemical mediators (e.g. prostaglandins, leukotrienes), interleukines, and the complement chain are involved in various types of allergic reactions. According to Gell and Coombs there are four classes of allergic or hypersensitivity reactions. (See Hypersensitivity reactions). Allergic reactions represent one third of adverse drug reactions. They are considered rare but with high morbimortality.

References

Nagao-Dias AT, Barros-Nunes P, Coelho HL, Solé D. Allergic drug reactions. J Pediatr (Rio J). 2004 Jul-Aug;80(4):259-66.