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Dictionary of Allergies .. Kiwi fruit (Chinese gooseberry; Actinidia chinensis)

Kiwi fruit (Chinese gooseberry; Actinidia chinensis)

Kiwi fruit has been reported to cause allergic symptoms (anaphylaxis, angioedema), in highly sensitive patients. Pollen allergic persons seem to be prone to develop allergy to kiwi fruit.F84 is the symbol of kiwi fruit in RAST[1]. Kiwi fruit is an important source of food allergens, the number and relevance of which are still the object of investigation[2]. Palacin A, et al (2008) isolated Act d 1, Act d 2 and Act d 3, the major kiwifruit allergens and explored their relevance by in vitro and in vivo methods in a large group (n=92) of kiwi-sensitized patients with different clinical symptoms. Severe symptoms after kiwi ingestion are associated with high IgE levels to Act d 1 and Act d 3. They performed double-blind, placebo-controlled, food challenges to kiwi in 52 of them. By N-terminal amino acid sequencing and molecular size and glycosylation analysis they isolated and characterized the three major IgE-binding proteins from kiwifruit extracts. 

The allergenic potency of the three kiwi allergens, and of avocado Pers a 1 as a model allergen associated with the latex-fruit syndrome, was tested by specific IgE quantitation, immunodetection assays and SPTs. The isolated kiwifruit allergens were identified as actinidin Act d 1, glycosylated thaumatin-like Act d 2 and a novel 40 kDa glycoprotein designated as Act d 3.02. Specific IgE to each of the three allergens was found in over 60% of sera from kiwi-sensitized patients, and Act d 1 and Act d 2 induced positive SPT responses in over 50% of the tested patients. A significant link between IgE levels to Act d 1 and Act d 3 and anaphylaxis was uncovered. Avocado Pers a 1 showed an in vitro sensitization prevalence of around 45%, but a low in vivo reactivity[3].


1. Macadam, R.A.:Anaphylaxis to kiwi fruit and exotic items - Macadamia nuts (Correspondence) J. Asthma 1984;2:231.

2. Ciardiello MA, Giangrieco I, Tuppo L, Tamburrini M, Buccheri M, Palazzo P, Bernardi ML, Ferrara R, Mari A. Influence of the natural ripening stage, cold storage, and ethylene treatment on the protein and IgE-binding profiles of green and gold kiwi fruit extracts. J Agric Food Chem. 2009 Feb 25;57(4):1565-71.

3. Palacin A, Rodriguez J, Blanco C, Lopez-Torrejon G, Sánchez-Monge R, Varela J, Jiménez MA, Cumplido J, Carrillo T, Crespo JF, Salcedo G. Immunoglobulin E recognition patterns to purified Kiwifruit (Actinidinia deliciosa) allergens in patients sensitized to Kiwi with different clinical symptoms. Clin Exp Allergy. 2008 Jul;38(7):1220-8. Epub 2008 Jan 19.

Γκέλης Ν.Δ. - Λεξικό Αλλεργίας - Εκδόσεις ΒΕΛΛΕΡOΦΟΝΤΗΣ - Κόρινθος 2013

Gelis Ν.D. - Dictionary of Allergies - VELLEROFONTIS Publications - Corinth 2013