Dictionary of Allergies .. CD23 antigen

A receptor who is identical to the FcεRII.  It is present in the normal body fluids and particularly in the germinal center, it is tempting to speculate that it is involved in the regulation of the differentiation and in the maturation of various cell types (T and B lymphocytes, monocytes, etc.). Evidence also indicates that CD23 could play an important regulatory role in the initiation of immune responses by acting as an adhesion molecule between B lymphocytes following IL-4 stimulation. It seems likely that CD23 is involved in the regulation of microenvironmental inflammatory and immune processes and more particularly in the development of allergic diseases.  CD23s is the soluble form of CD23 and acts as an IgE-binding factor to enhance IgE synthesis (Saxon 1990).

References

Dugas, B., et al:  Role of CD23 in the regulation of the immune response: possible relevance to clinical disorders.  In Advances in Allergology and Clinical Immunology ed. by Ph. Godard et al:  EAACI Congress in Paris, 10-15 May 1992.

Saxon, A., et al: Soluble CD23 containing B cell supernatants induce IgE from peripheral blood B-lymphocytes and costimulate with interleukin-4, in induction of IgE. J. Allergy Clin. Immunol. 86, 333-44.55