Dictionary of Allergies .. Adenosine monophosphate (cyclic AMP)

Adenosine monophosphate (cyclic AMP)

Adenosine monophosphate (AMP) causes bronchoconstriction indirectly, through degranulation of primed mast cells and consequent release of proinflammatory mediators, such as histamine and leukotrienes, as well as through neuronal mechanisms [1]. AMP challenge is a more sensitive marker of change during treatment with corticosteroids [2], as well as being more asthma-specific than direct challenge.see cyclic nucleotides, Adenylcyclase.

References

1.Polosa R, Holgate ST. Adenosine bronchoprovocation: a promising marker of allergic inflammation in asthma? Thorax 1997;52: 919-923.

2.Wilson AM, Lipworth BJ. Dose-response evaluation of the therapeutic index for inhaled budesonide in patients with mild-to-moderate asthma. Am J Medical 2000;108: 269-275.