Dictionary of Allergies .. Adenosine diphosphate (ADP),

Adenosine diphosphate (ADP),

Cyclic nucleotides. The nucleoside adenosine consists of the ourine base adenine in glycoside linkage with the sugar ribose. Most adenosine is derived from cleavage of of the nucleotide adenosine 5΄-monophosphate (AMP) by an enzyme specific for the 5΄-nucleotides, 5΄-nucleotidase, which is principally associated with the cell plasma membrane. The majority of intracellular AMP is formed by cleavage of the high-energy phosphate bonds of adenosine diphosphate (ADP) and adenosine triphosphate (ATP) during the process of energy generation. In normal conditions most of this AMP is reconverted to ADP and ATP, but under conditions of high energy demand and/or hypoxia AMP is metabolised to adenosine by 5΄-nucleotidase, so that more energy can be released.

References

Bodansky O., SCHwartz MJ, 5΄-Nucleotidase. Adv. Clin. 1968;11:277-328