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Λεξικό .. Viral induced asthma

Viral induced asthma,ιογενές άσθμα. Viral infections, predominantly with rhinovirus, account for up to 85% of childhood asthma exacerbations, daily symptoms, and exacerbations in children [1] and adults [2] with asthma. Evidence suggests that leukotrienes play a key role in viral induced respiratory illness. The leukotriene C4 concentrations in nasopharyngeal secretions of young children with viral-induced wheeze was elevated compared with children who reacted only with upper airway symptoms [3] and can be detected up to 28 days after the onset of viral-induced respiratory illness [4],

suggesting the need for long-term treatment. Viral-induced asthma exacerbations are seasonal, but seem to occur year-round outside the summer [5]. Patients demonstrate few exacerbations and few or no asthma symptoms during the summer season in the Northern and Southern hemispheres. The distribution of exacerbations episodes over the year wasmore consistent with viral exacerbations than allergy-related exacerbations. Although some exacerbations could be associated with allergies, the timing of the exacerbations over the year and the consistent effect in patients with and without allergic rhinitis suggest that the majority of exacerbations were likely viral-induced[6].

References

1.Johnston SL, Pattemore PK, Sanderson G, Smith S, Lampe F, Josephs L, Symington P, O’Toole S, Myint SH, Tyrrell DAJ, et al. Community study of the role of viral infections in exacerbations of asthma in 9–11 year old children. BMJ 1995;310:1225–1229.

2. Nicholson KG, Kent J, Ireland DC. Respiratory viruses and exacerbations of asthma in adults. BMJ 1993;307:982–986.

3. van Schaik SM, Tristram DA, Nagpal IS, Hintz KM, Welliver RC II,Welliver RC. Increased production of IFN-gamma and cysteinyl leuko322 AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE VOL 171 2005 trienes in virus-induced wheezing. J Allergy Clin Immunol 1999;103:630–636.

4. Volovitz B, Welliver RC, De Castro G, Krystofik DA,

Ogra PL.
The release of leukotrienes in the respiratory tract during infection with respiratory syncytial virus: role in obstructive airway disease. Pediatr Res 1988;24:504–507.

5. Johnston SL,

Pattemore PK
, Sanderson G, Smith S, Campbell MJ, Josephs LK, Cunningham A, Robinson BS, Myint SH, Ward ME, et al. The relationship between upper respiratory infections and hospital admissions for asthma: a time-trend analysis. Am J Respir Crit Care Med 1996;154:654–660.
6. Bisgaard H, Zielen S, Garcia-Garcia ML, Johnston SL, Gilles L, Menten J, Tozzi CA, Polos P. Montelukast reduces asthma exacerbations in 2- to 5-year-old children with intermittent asthma. Am J Respir Crit Care Med. 2005 Feb 15;171(4):315-22. Epub 2004 Nov 12.

Γκέλης Ν.Δ. - Λεξικό Αλλεργίας - Εκδόσεις ΒΕΛΛΕΡOΦΟΝΤΗΣ - Κόρινθος 2013

Gelis Ν.D. - Dictionary of Allergies - VELLEROFONTIS Publications - Corinth 2013