Λεξικό .. Phadia CAP System FEIA

Phadia CAP System FEIA: The Phadia CAP System FEIA is a commercial method for quantification of specific IgE The CAP System FEIA employs a type of "architecture" whereby the allergen of interest is covalently bound to a hydrophilic carrier polymer, encased in a capsule, which catches all allergen-specific IgE in the sample. Allergen-specific IgE is detected directly with a combination of polyclonal and monoclonal anti-IgE (F c) antibodies labeled with beta-galactosidase, generating fluorescence. 2006, tests for anti-beta-lactam IgE antibody in patients with total IgE > 500 kU/l were probably often false positive. Patients who were diagnosed as penicillin allergic before 2006 solely on the basis of a positive CAP FEIA test for specific IgE should be considered for diagnostic reevaluation.

References

Zidarn M, Silar M, Vegnuti M, Korosec P, Kosnik M. The specificity of tests for anti-beta-lactam IgE antibodies declines progressively with increase of total serum IgE. Wien Klin Wochenschr. 2009;121(9-10):353-6