Λεξικό .. Bacterial vaccines

The bacterial infections in patients with acute exacerbation of asthma has led to the hypothesis that such infections could play a crucial role in the induction and exacerbation of asthma (bronchial asthma of infectious origin). After that  it seems logical the attempt to modify the course of the disease by immunologic intervention in bacterial infections. In the 1940s and '50s, the success (partly inspired by the lack of effective antiasthma pharmacologic treatment) of immunotherapy (desensitization; hyposensitization) with inhalant allergens suggested that the clinical outcome of asthma treatment could be improved by injecting bacterial antigens. Several – mostly open studies – have evaluated the beneficial effect of bacterial immunotherapy in patients with bronchial asthma. The clinical effect has recently been questioned, and international recommendations clearly state that bacterial vaccines have no role in modern asthma treatment

References

Malling HJ. Bacterial vaccines: anything but placebo. Allergy. 2000 Mar;55(3):214-8.