Dictionary of Allergies .. topical antihistamines
Some topical preparations containing antihistamine are still available. Direct application of antihistamines to the skin has been recognised as frequently dealing to sensitivity reactions, sometimes quite severe. The reaction thus provoked may indeed be much more of a problem than the insect sting or bite which was the initial event. The topical application of levocabastine- a potent H1 -antagonist (second generation H1 receptor, long acting antagonist) yielded good clinical results in allergic conjunctivitis, seasonal allergic rhinoconjunctivitis, and non allergic perennial rhinitis. Topical antihistamine agents are administered in order to avoid the side effects of systemically applied medications, and to reach higher local drug concentrations. H1 receptors of the nasal mucosa play an important role in the physiopathology of allergic and non allergic rhinitis and even of infectious rhinitis.(See Levocabastine, Livostin).
Van De Heyning. A gap in surface therapy: topical antihistamines. Session at the Annual Meeting of the EAACI Glasgow (O.K.) July 11, 1990. Wood, S.F.: Choosing an Antihistamine Prescribers. Journal, 28(1), 21-24, (1988).
Γκέλης Ν.Δ. - Λεξικό Αλλεργίας - Εκδόσεις ΒΕΛΛΕΡOΦΟΝΤΗΣ - Κόρινθος 2013
Gelis Ν.D. - Dictionary of Allergies - VELLEROFONTIS Publications - Corinth 2013