. Allergopedia

Dictionary of Allergies .. Rupatadine

Rupatadine (Rupafin®. Rinialer®, Rupax®. Alergoliber®) is a selective oral histamine Hi-receptor antagonist that has also been shown to have platelet-ac­tivating factor (PAF) antagonist activity in vitro. It is indicated for use in seasonal allergic rhinitis (SAR). perennial allergic rhinitis (PAR) and chronic idiopathic urticaria (CIU) in patients aged >12 years.

Clinical trials show that rupatadine is an effective and generally well tolerated treatment for allergic rhinitis and CIU. It has a rapid onset of action and a prolonged duration of activity. Importantly, it has no significant effect on cogni­tion, psychomotor function or the cardiovascular system. Once-daily rupatadine significantly improves allergic rhinitis symptoms in patients with SAR, PAR or persistent allergic rhinitis (PER) compared with placebo, and provides similar symptom control to that of loratadine, desloratadine, cetirizine or ebastine. In patients with CIU. longer-term use of rupatadine improves CIU symptoms to a greater extent than placebo. It is as well tolerated as other commonly used second-generation Η ι-receptor antagonists. Thus, the introduction of rupatadine extends the range of oral agents available for the treatment of allergic disorders, including allergic rhinitis and CIU.

References

Keam SJ, Plosker GL. Rupatadine. A Review of its Use in the Management of Allergic Disorders. Drugs 2007;67(3): 457-474.

Γκέλης Ν.Δ. - Λεξικό Αλλεργίας - Εκδόσεις ΒΕΛΛΕΡOΦΟΝΤΗΣ - Κόρινθος 2013

Gelis Ν.D. - Dictionary of Allergies - VELLEROFONTIS Publications - Corinth 2013