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Dictionary of Allergies .. Malignant idiopathic anaphylaxis

Malignant idiopathic anaphylaxis

A severe form of corticosteroid-dependent idiopathic anaphylaxis. The term malignant does not imply neoplasm, but describes a severe disease that is resistant to treatment and  may be fatal. Malignant idiopathic anaphylaxis refers to the most severe form of idiopathic anaphylaxis where defined episodes of idiopathic anaphylaxis are not controlled when the prednisone is reduced below at least 60 mg every other day or 20 mg daily, without recurrence of idiopathic anaphylaxis episodes during at least 2 months [1]. Ketotifen is shown to be successful in inducing remission in two patients with malignant idiopathic anaphylaxis and in three additional patients with corticosteroid-dependent idiopathic anaphylaxis. An additional patient with malignant idiopathic anaphylaxis had prednisone stopped after elective hip surgery[2].


References

1. Stoloff, R.S.: Malignant idiopathic anaphylaxis: Three additional cases and extended evaluation. Annals of Allergy Vol. 69, p. 37, July 1992.

2. Patterson R, Fitzsimons EJ, Choy AC, Harris KE. Malignant and corticosteroid-dependent idiopathic anaphylaxis: successful responses to ketotifen. Ann Allergy Asthma Immunol. 1997 Aug;79(2):138-44.

Γκέλης Ν.Δ. - Λεξικό Αλλεργίας - Εκδόσεις ΒΕΛΛΕΡOΦΟΝΤΗΣ - Κόρινθος 2013

Gelis Ν.D. - Dictionary of Allergies - VELLEROFONTIS Publications - Corinth 2013