Dictionary of Allergies .. A-Kinase (cAMP dPK)
A-Kinase (cAMP dPK)
A-Kinase (cAMP dPK),
Cyclic AMP dependent protein kinase. A family of enzymes activated by cyclic AMP, which catalyse intracellular phosphorylation reactions.
Protein scaffold complexes are a key mechanism by which a common signaling pathway can serve many different functions. Sequestering a signaling enzyme to a specific subcellular environment not only ensures that the enzyme is near its relevant targets, but also segregates this activity to prevent indiscriminate phosphorylation of other substrates. One family of diverse, well-studied scaffolding proteins are the A-kinase anchoring proteins (AKAPs). These anchoring proteins form multi-protein complexes that integrate cAMP signaling with other pathways and signaling events.
Carnegie GK, Means CK, Scott JD. A-kinase anchoring proteins: from protein complexes to physiology and disease. IUBMB Life. 2009 Apr;61(4):394-406.
Γκέλης Ν.Δ. - Λεξικό Αλλεργίας - Εκδόσεις ΒΕΛΛΕΡOΦΟΝΤΗΣ - Κόρινθος 2013
Gelis Ν.D. - Dictionary of Allergies - VELLEROFONTIS Publications - Corinth 2013